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Underwater endoscopic mucosal resection (UEMR) is a polypectomy technique where the colon lumen is filled with water and resection performed without submucosal fluid injection. Although UEMR has been shown to be effective and safe, it is not widely performed and is used mostly for large (≥20 mm) polyps.
In a multicenter, randomized, controlled trial in Japan, researchers investigated whether UEMR is superior to conventional EMR for sessile and superficial elevated polyps 10 to 20 mm in size. The procedures were performed by 28 endoscopists with varying degrees of experience, and 210 patients with 210 lesions were included. The primary endpoint was R0 resection, defined as en bloc resection with a histologically negative resection margin. Com…