Loading...
Some 20% of pregnancies end in miscarriage (spontaneous loss after recognition of a clinical pregnancy and before 20 weeks' gestation), and exogenous progesterone has produced inconsistent results. To test whether vaginal progesterone could increase the likelihood of live birth in the setting of threatened miscarriage, U.K. investigators randomized 4153 women (age range, 16–39) with vaginal bleeding before 12 weeks' gestation and a sonographically identified intrauterine gestational sac to progesterone (400-mg vaginal suppository twice daily) or placebo through 16 completed weeks.
Rates of live birth after ≥34 weeks' gestation did not differ between the progesterone and placebo groups (75% and 72%; relative rate, 1.03; P=0.08). Likelihood of…