Long-Term Risk for Chronic Kidney Disease After Premature Birth

Prematurity and extreme prematurity were associated with doubled and tripled risks, respectively, for CKD from childhood into mid-adulthood.

Because much of nephrogenesis occurs late in gestation, what is the impact of premature birth upon renal function later in life?

To address this question, researchers used Swedish birth and health registries to examine the risk for chronic kidney disease (CKD) in childhood through mid-adulthood among 4.2 million residents by birth term status: extremely preterm (22–27 weeks, very preterm (28–33 weeks), late preterm (34–36 weeks), early term (37–38 weeks), term (39–41 weeks), and post-term (≥42 weeks). Results were as follows:

CKD developed in 4305 individuals (0.1%) during 87 million person-years of follow-up.
Incidence rates of CKD were 9.2 per 100,000 person-years for all preterm births combined, 5.9 for early term, and 4.5 for term births.
I…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Long-Term Risk for Chronic Kidney Disease After Premature Birth

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Reviewing Author