Loading...
Limbic-predominant age-related TDP-43 encephalopathy (LATE), a recently recognized encephalopathy, has features of Alzheimer disease but is distinct from it. It's still a disease without an agreed-upon name, according to a Brain review.
A working group on LATE describes it as “proteinopathy of advanced age, especially in subjects older than age 80.” The protein has a molecular weight of 43 kilodaltons and usually is found in the cell nucleus, but in LATE, it's also found in the cytoplasm.
The disease brings on “substantial disease-specific cognitive impairment ... of the Alzheimer's type.”
The authors, citing the presence of the proteinopathy in over 20% of people older than 80, say “the public health impact of LATE is likely to be quite signi…