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Subclinical hypothyroidism, defined as elevated blood thyroid-stimulating hormone (TSH) and normal free thyroxine levels, is not uncommon. For this guideline, researchers reviewed 21 randomized controlled trials that involved more than 2000 adults with subclinical hypothyroidism who received thyroid hormone treatment or placebo.
Moderate-to-high–quality evidence suggests that thyroid hormone treatment does not improve quality of life or potential thyroid-related symptoms (e.g., depression, fatigue, high body-mass index).
Low-quality evidence suggests that thyroid hormone treatment has little or no effect on risks for adv…