Bipolar Disorder and Heightened Risk for Parkinson Disease

Longitudinal results from a national Taiwanese database

Parkinson disease (PD) has a complicated relationship with psychiatric disorders. Some medications used to treat PD can lead to psychosis or compulsive behavior; some psychiatric medications can produce parkinsonian symptoms; and individuals with PD can develop psychiatric disorders, especially depression, as part of the neurologic disease. Also, risk for PD is elevated in patients with major depressive disorder. To learn about possible connections between PD and bipolar disorder (BD), researchers used a large Taiwanese database to examine new diagnoses of PD in 56,340 patients diagnosed with BD from 2001 to 2009 (time of enrollment) and in 225,360 age- and sex-matched controls.

Follow-up lasted through 2011. People with BD had a significant…

Reviewing Author

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Bipolar Disorder and Heightened Risk for Parkinson Disease

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Reviewing Author