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Naltrexone, an opioid blocker available as an oral daily pill, a monthly long-acting injection, and a multimonth subcutaneous implant, is one of several treatments for opioid use disorder (OUD); it improves clinical outcomes and reduces mortality. Unlike buprenorphine or methadone, naltrexone has a low diversion risk, as it has no opioid-agonist or euphoric effects. However, it also reduces tolerance to opioids, and patients who relapse after discontinuing naltrexone face an elevated risk for overdose. To learn more about this risk, researchers conducted a postmortem study of 74 OUD cases in Australia (60 men; mean age, 33) who had been prescribed naltrexone (oral prescription within previous month, 62%; implant within the previous 6 months…