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Lifestyle and genetic factors can affect risk for dementia, but their relative effects have been unclear. To determine whether lifestyle behaviors influence dementia risk, regardless of genetic risk, researchers conducted a retrospective cohort study using data from 196,383 white participants aged ≥60 years (mean age, 64; 53% women) in the United Kingdom Biobank. High, intermediate, or low genetic risk was based on polygenic risk scores calculated from single nucleotide polymorphisms associated with Alzheimer disease. A favorable, intermediate, or unfavorable lifestyle was based on an overall lifestyle score from self-reported smoking status, physical activity, diet, and alcohol consumption. All-cause dementia was identified by review of me…