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Patients with heart failure (HF) and nonobstructive coronary artery disease (CAD) often are classified as having nonischemic cardiomyopathy, but does nonobstructive CAD affect their prognosis? In a cohort of 12,814 Canadian patients with HF and reduced ejection fraction (HFrEF), 20.7% had normal coronary arteries, 17.6% had nonobstructive CAD (defined as <50% stenosis in the left main coronary artery and <70% in the other major coronary arteries), and 61.7% had obstructive CAD.
Compared with having normal coronary arteries, having nonobstructive CAD was associated with significantly higher risk for a composite outcome of cardiovascular-related death, nonfatal myocardial infarction, nonfatal stroke, or HF-related hospitalization (hazard ratio…