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Hypertrophic cardiomyopathy (HCM) is a clinical diagnosis, usually made when there is cardiac hypertrophy in the absence of any loading condition. However, other conditions — in particular, storage diseases, infiltrative diseases, and even hypertension — can mimic HCM. In the largest pathologic series of its type, researchers examined specimens from 2472 consecutive patients diagnosed with HCM who underwent myectomy.
All patients had a clinical diagnosis of HCM with severe left ventricular outflow tract obstruction. Interestingly, histopathologically confirmed HCM in the absence of other conditions was present in only 82%. Hypertensive heart disease (hypertrophy without myocardial disarray, myocyte hypertrophy, arteriole dysplasia, and fibro…