Ejection Fraction Has a U-Shaped Relationship with Mortality

LVEFs above or under 60% to 65% were associated with elevated all-cause mortality in an observational study.

Left ventricular ejection fraction (LVEF) is a commonly used prognostic indicator of cardiovascular disease risk and outcomes. Investigators used clinical databases to understand the relationship between physician-reported LVEF and survival.

The primary analysis was performed on 403,977 echocardiograms from 1998 to 2018 in 203,135 unique patients in a U.S. regional health system (mean age, 64; 52% men). Indications for echocardiograms varied widely, with the top five being chest pain, dyspnea/fatigue, coronary artery disease, aortic valve disease, and heart failure. After a median follow-up of 4 years, 23% of the patients died. Analyses adjusting for age, sex, comorbidities, and other echocardiographic features identified a U-shaped relation…

Reviewing Author

Fatima Rodriguez, MD, MPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardNovoNordisk; HealthPals; Novartis; Amgen

EquityHealthPals; Carta

Grant/Research SupportNational Institutes of Health/National Heart, Lung, and Blood Institute; American Heart Association–Robert Wood Johnson Foundation

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