Clarity on Antithrombotic Therapy for Atrial Fibrillation plus Chronic CAD

Finally, we can be sure that anticoagulation without an antiplatelet agent is best for patients with atrial fibrillation and chronic coronary artery disease.

Several randomized, controlled trials (e.g., RE-DUAL; NEJM JW Cardiol Aug 27 2017; [e-pub] and N Engl J Med 2017; 377:1513) have shown that for most patients with atrial fibrillation (AF), the standard of care for the first year after percutaneous coronary intervention (PCI) is anticoagulation plus a single antiplatelet agent. However, pertinent data more than 1 year after PCI have been limited. AFIRE, a randomized trial from Japan (NCT02642419), provides clarity on optimal antithrombotic therapy in this population.

Researchers randomized 2236 patients with AF who had undergone PCI or coronary artery bypass grafting at least 1 year earlier, or who had a history of angiographically confirmed coronary artery disease (CAD; stenosis ≥50%) not re…

Reviewing Author

Mark S. Link, MD

Disclosures

Editorial BoardsCirculation; UpToDate

Mark S. Link, MD

Disclosures

Editorial BoardsCirculation; UpToDate

Clarity on Antithrombotic Therapy for Atrial Fibrillation plus Chronic CAD

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Reviewing Author