A New Option for Treatment-Refractory Multiple Myeloma

Multiple myeloma patients who are refractory to the three major classes of targeted therapies — proteasome inhibitors, immunomodulatory agents, and the anti-CD38 monoclonal antibody daratumumab — have limited treatment options and poor survival.

Now, investigators have conducted an industry-sponsored, multicenter, open-label, phase IIb trial of the exportin 1 inhibitor selinexor in 123 multiple myeloma patients with prior exposure to bortezomib, carfilzomib, lenalidomide, pomalidomide, daratumumab, and an alkylating agent (median number of prior regimens, 7). Of these patients, 102 had undergone prior stem-cell transplantation, 2 had received prior CAR-T cell therapy, and 118 were refractory to carfilzomib, pomalidomide, and daratumumab. Pat…