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The poor overall survival (OS) associated with double-hit (DH) or triple-hit (TH) MYC rearrangement status plus BCL2 or BCL6 rearrangement is well recognized in diffuse large B-cell lymphoma (DLBCL). However, the prognostic relevance of isolated (single-hit) MYC rearrangement remains controversial.
To address this issue, investigators conducted an international, retrospective study involving 2383 DLBCL patients from prospective therapeutic trials or patient registries who received first-line immunochemotherapy with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) or an equivalent regimen and had biopsy samples available for analysis. Samples were assessed for MYC rearrangement with an immunoglobulin (Ig) ver…