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Post-traumatic stress disorder (PTSD) is diagnosed based on self-reported symptoms. Because of perceived stigma, patients sometimes don't seek help (resulting in underdiagnosis); conversely, some patients fabricate symptoms for secondary gain (resulting in overdiagnosis). In the past decade, technologies that allow measurement of thousands of molecules of various types (“multi-omics”) in a single specimen of blood have been developed with the hope of finding objective “fingerprints” of specific diseases. Might PTSD be amenable to objective multi-omic evaluation?
Multi-omic data was collected from 77 warzone-exposed patients with confirmed PTSD and from 74 warzone-exposed, non-PTSD controls. A combination of 28 biomarkers of various types (ro…