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Recent concerns about the risks of taking antidepressants have arisen from randomized, controlled studies. For another perspective, investigators conducted an umbrella review of 45 meta-analyses of 695 observational studies of antidepressants. All studies used valid control groups; the median follow-up was 4 years.
Analyses initially identified apparently significant associations of antidepressant use with suicidality in children and adolescents, autism spectrum disorder and attention-deficit/hyperactivity disorder after intrauterine exposure, cataracts, bleeding, osteoporosis, fractures, and pregnancy complications such as preterm birth. However, after controlling for confounding by the disorder for which the antidepressant was prescribed, …