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Colonoscopic surveillance after adenoma removal is based on risk stratification according to adenoma number, size, and histologic characteristics. However, the current definitions of low-risk (1–2 adenomas <10 mm in diameter) and high-risk (≥3 adenomas, size ≥10 mm, villous pattern, or high-grade dysplasia [HGD]) are not supported by strong evidence, as most studies have used advanced adenomas as a surrogate for colorectal cancer (CRC).
In this study, investigators identified over 236,000 individuals (median age, 56 years; 38% men) who underwent screening colonoscopies in the Polish National Colorectal Cancer Screening Program from 2000 through 2011 and were followed for up to 14 years. The results were as follows:
Compared with individuals w…