5-Aminosalicylate Use Is Not Associated with Chronic Kidney Disease in IBD

Patients with inflammatory bowel disease (IBD) are at risk for extraintestinal manifestations including renal disease. One suspected pathway to development of chronic kidney disease (CKD) is use of 5-aminosalicylates (5-ASAs), which has been associated with idiosyncratic interstitial nephritis and for which serial monitoring of kidney function is recommended. However, data are conflicting about true risk of 5-ASAs in this setting.

Researchers retrospectively assessed the risk for CKD in more than 17,800 patients with inflammatory bowel disease (IBD) and more than 63,000 age-, sex-, and practice-matched controls without IBD. They examined possible roles of 5-ASAs and other nonbiologic IBD drugs. Estimated glomerular filtration rate (eGFR) was…