More Data Highlight the Linkage Between Premature Menopause and Incident CVD

Observational data from the U.K. show an association with cardiovascular disease, whether early menopause is natural or surgical.

Early menopause is associated with increased risk for cardiovascular disease (CVD), and the American Heart Association/American College of Cardiology's 2019 guidelines factor a history of premature menopause (onset before age 40) into CVD risk assessments and recommendations for midlife women. To refine CVD risk estimates for natural and surgical (bilateral oophorectomy) premature menopause, investigators recruited 144,260 eligible postmenopausal women (age range, 40–69; 95% white) from the U.K. Biobank between 2006 and 2010. Mean age at menopause was 50.3 years among women without premature menopause (96.2% of the cohort), 35.4 among those with natural premature menopause (3.4%), and 34.2 among those with surgical premature menopause (0.4%…

Reviewing Authors

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

JoAnn E. Manson, MD, DrPH

More Data Highlight the Linkage Between Premature Menopause and Incident CVD

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Reviewing Authors