Subclinical Cardiovascular Disease Not Increased in HIV Elite Controllers

Levels of carotid artery plaque and coronary artery calcium were similar for HIV controllers, long-term nonprogressors, and HIV-uninfected persons.

Numerous reports have suggested that HIV+ persons are at increased risk for cardiovascular disease, due to effects of HIV infection on inflammation/immune activation and, in some cases, perhaps from adverse effects of antiretroviral therapy (ART) drugs. Persons with HIV who do well without treatment allow for an assessment of subclinical cardiovascular disease. Such people include elite controllers (ECs; HIV level undetectable without ART), viremic controllers (VCs; HIV level <200 copies/mL without ART), and long-term nonprogressors (LTNPs; CD4 >500 copies/mL for at least 5 years without ART).

These investigators assessed carotid artery plaque, carotid intima-media thickness (IMT), coronary artery calcification (by computed tomography), and …

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Subclinical Cardiovascular Disease Not Increased in HIV Elite Controllers

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Reviewing Author