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For over 20 years, endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA) samples have been evaluated by standard cytologic means, often by an onsite pathologist. In rapid onsite evaluation (ROSE), an onsite pathologist creates and examines the smeared cytology slides in real time. While highly effective, ROSE is time- and labor-consuming and can be difficult to arrange at some centers. The simpler process of liquid-based cytology (LBC) involves taking cytologic samples, placing them into a special medium, and using a machine to create slides for later viewing. Although LBC has been studied in many contexts, few data exist on its use in EUS-FNA sampling.
In a recent prospective, randomized, noninferiority study, investigators compared…