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To clarify whether children conceived as a result of fertility treatment are at excess risk for cancer, investigators linked the Danish health registry with the infertility cohort, resulting in 12.2 million person-years of follow-up (mean, 11.3 years) and identifying 2217 cases of cancer among >1,000,000 children from 1996 through 2012.
Incidence rates of childhood cancer were 17.5 per 100,000 children-years in those born to fertile women, 17.1 following fresh embryo in vitro fertilization (IVF), and 23.1 following intracytoplasmic sperm injection (ICSI). In contrast, the incidence rate was 44.4 among children conceived using cryopreserved embryos (hazard ratio, 2.4). Although the total number of cancer cases was small, children conceived us…