Report from the 61st American Society of Hematology Annual Meeting — Benign Hematology

Presenters at the recent meeting of the American Society of Hematology (ASH; December 7–10, 2019, in San Diego, CA) reported the latest research in hematology. Here, NEJM Journal Watch Oncology and Hematology Associate Editor Dr. Brady Stein describes the key findings. The original abstracts can be found on the ASH website.

Complement Activation in Antiphospholipid Antibody Syndrome

The pathophysiology of thrombosis and other clinical manifestations in the antiphospholipid antibody syndrome (APS) has mystified hematologists. However, increasing evidence, including in a study by Chaturvedi and colleagues (plenary abstract 4), implicates complement activation in APS pathogenesis.

First, the investigators utilized a functional assay (modified Ham…