Loading...
Intestinal dysbiosis may contribute to the pathogenesis of irritable bowel syndrome (IBS), but studies of fecal microbiota transplantation (FMT) to treat IBS have yielded inconsistent results.
To further address this issue, investigators in Norway randomized 165 IBS patients 1:1:1 to receive 30 g FMT using their own stool (placebo group) or 30 g or 60 g FMT using stool from a single healthy donor. All patients fulfilled Rome IV criteria for IBS and had moderate-to-severe symptoms for a mean of 17 years. The stool used for FMT was frozen and administered in the duodenum using an upper endoscope. Response (the primary outcome) was defined as a decrease of ≥50 points in the total IBS symptom score after 3 months.
The results were as follows:
Resp…