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Sialorrhea is a common disorder that is frequently seen in patients with Parkinson disease, amyotrophic lateral sclerosis, and cerebral palsy. Injection of rimabotulinumtoxinB into the salivary glands inhibits salivary production and was previously shown to be safe and well tolerated.
Now, researchers report on a phase 3, manufacturer-sponsored, randomized, parallel, double-blind, placebo-controlled trial to assess the safety, tolerability, and efficacy of rimabotulinumtoxinB (2500 and 3500 U) injections for the treatment of sialorrhea. Investigators enrolled 187 patients with sialorrhea: 147 were male, 122 had Parkinson disease, 13 had prior stroke, 12 had amyotrophic lateral sclerosis, 6 had medication-induced sialorrhea, 4 had adult cereb…