Can Cervical Cancer Be Eliminated?

High coverage with HPV vaccine, screening, and follow-up are predicted to have an impact on global incidence and mortality — but not for a while.

The WHO has called for cervical cancer's elimination (defined as ≤4 cases per 100,000 women-years globally). To estimate the potential impact of human papillomavirus (HPV) vaccination and cervical screening with HPV assays on cervical cancer incidence and mortality, researchers modelled the effects of the following interventions in 78 lower- and middle-income countries (LMIC):

Girls-only HPV immunization at age 9 with catch-up in the first year to age 14
HPV immunization of girls plus 1 lifetime cervical screening at age 35
HPV immunization of girls plus 2 lifetime screenings at ages 35 and 45

Modeling assumptions were that the vaccine covers 7 oncogenic HPV types included in the 9-valent vaccine (Gardasil-9), coverage will reach 90%, protectio…

Reviewing Author

Anna Wald, MD, MPH

Disclosures

Consultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)

RoyaltiesUpToDate

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris

Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases

Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)