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Endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA) of pancreatic masses has an excellent safety record and provides a high rate of diagnostic tissue acquisition. Still, not every patient undergoing EUS-FNA receives a definitive diagnosis, and subsequent options include repeating the EUS-FNA, obtaining a computed tomography scan, conducting transabdominal-guided needle biopsy, or performing surgical biopsy. A recent meta-analysis evaluated outcomes in patients undergoing repeat EUS-FNA after a negative or nondiagnostic result.
Twelve studies comprising 505 patients were included. Overall, the sensitivity, specificity, and positive- and negative-predictive values of repeat EUS-FNA were 77%, 98%, 99%, and 61%, respectively. Rapid ons…