Hydration Before Contrast-Enhanced CT in Patients with Chronic Kidney Disease?

In a randomized trial, sodium bicarbonate prehydration was not beneficial before computed tomography.

The established practice of prehydration for patients with chronic kidney disease (CKD) who are undergoing contrast-enhanced computed tomography (CT) with intravenous iodinated contrast is not supported fully by randomized trial evidence. In this Dutch study, researchers randomized 523 adults (median age, 74) with stage 3 CKD to no prehydration versus prehydration with 250 mL of 1.4% sodium bicarbonate infused during 1 hour before outpatient contrast-enhanced CT. Roughly half of each group had baseline estimated glomerular filtration rates (eGFRs) of 30 to 44 mL/minute/1.73 m², and half had eGFRs of 45 to 59 mL/minute.

Mean relative increases in serum creatinine levels were similar in the two groups at 2 to 5 days following their procedures …

Reviewing Author

Thomas L. Schwenk, MD

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Thomas L. Schwenk, MD

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Hydration Before Contrast-Enhanced CT in Patients with Chronic Kidney Disease?

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Reviewing Author