Cytomegalovirus T-Cell Responses Predict CMV Infection and Disease After Renal Transplant

In a prospective study, renal transplant recipients with ≥20 positive spots in a T-spot assay using a CMV protein were less likely to develop infection or disease than those with <20 spots.

Risk assessment for cytomegalovirus (CMV) infection and disease among transplantation recipients is based on donor and recipient serostatus. However, this stratification is not always predictive. Measuring CMV-specific cell-mediated immunity (CMI) could be a more precise measure of the risk for CMV disease in transplant recipients. To assess this further, investigators performed a prospective, multicenter, observational study of 160 renal transplant recipients who were both donor and recipient CMV seropositive. Participants were stratified into high-risk and low-risk CMI groups based on whether they produced <20 or ≥20 interferon-gamma spots per 3 x 10⁵ peripheral blood mononuclear cells in response to incubation with the CMV immediate-earl…

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Cytomegalovirus T-Cell Responses Predict CMV Infection and Disease After Renal Transplant

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Reviewing Author