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Clinicians need tools to help distinguish bipolar disorder (BD) from major depressive disorder (MDD). Accurate BD diagnosis on clinical grounds alone is challenging, especially if individuals have hypomania; BD often presents first with a depressive episode, not mania; and antidepressants can trigger mania in BD. Therefore, many clinicians have placed hope in genetic differentiation between the two disorders. Because many genes are involved, determination of genetic risk for BD or MDD would depend on polygenic risk scores (PRSs) based on multiple markers in aggregate and derived from genome-wide association studies. Early work has indicated that PRSs can predict response to lithium in BD. These researchers genotyped and phenotyped 843 indiv…