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Studies of brain-circuit connectivity suggest distinctive biotypes for depressive disorders, aligned with clinical features such as anhedonia, anxiety, or rumination. These biotypes augment traditional clinical classifications of major depression (e.g., melancholic, agitated, or atypical subtypes). Employing a contrasting strategy, investigators asked whether high-frequency transcranial magnetic stimulation (TMS) targeting specific brain regions might yield improvement in specific mood-associated symptoms.
The researchers analyzed two datasets of patients with treatment-resistant major depression receiving TMS; they established normal connectivity of the targeted brain regions from a brain connectome database (N=1000). The discovery dataset …