Does Electrosurgical Current Setting Affect Outcomes After Polypectomy?

Electrosurgical snare resection is routinely used for polypectomy, but the optimal current types and settings are unclear due to sparse evidence.

In an industry-funded, multicenter, randomized, controlled, 2×2 factorial trial, investigators assessed more than 900 patients who underwent endoscopic mucosal resection (EMR) of large (≥20 mm) non-pedunculated polyps. Patients were assigned to receive either clip closure or no clip closure of the resection defect, and then to receive either a pure coagulation current (Forced Coagulation) or a blended-cut coagulation current (Endocut).

A prior analysis showed that clip closure significantly reduced bleeding risk (NEJM JW Gastroenterol Jun 2019 and Gastroenterology 2019; 157:977). Now, the investigat…