Mycoplasma genitalium Urethritis: Prevalence and Drug-Resistance Patterns

Mycoplasma genitalium (MG) is increasingly recognized as a cause of male urethritis, and recent studies indicate increasing prevalence of macrolide-resistance mutations (MRMs). In a study sponsored by the Centers for Disease Control and Prevention, investigators evaluated the prevalence, drug resistance, and outcomes of men with urethritis in six geographically diverse sexually transmitted disease (STD) clinics in the U.S. Enrolled patients with clinically and laboratory-confirmed urethritis provided urethral and urine samples at baseline for the nucleic acid detection of pathogens and macrolide- and quinolone-associated resistance mutations. Patients were treated per the local standard of care and were followed for 14 to 17 days to assess …