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Many of the core features of borderline personality disorder (BPD; irritability, impulsivity, emotional instability) suggest disruption in frontolimbic brain circuits. Imaging studies have shown disruptions in the uncinate fasciculus, a white-matter tract connecting prefrontal regions to paralimbic temporal regions. The present researchers used diffusion tensor imaging to examine white-matter integrity in prefrontal fiber tracts in 18 women with BPD and 38 psychiatrically healthy controls.
Significant increases in radial diffusivity were seen in the right prefrontal white matter of people with BPD in a region correlated with the uncinate fasciculus, inferior anterior thalamic radiation, and fronto-occipital fasciculus. Similar increases in a…