Mortality in E. coli Bloodstream Infections: Does Resistance Matter?

Pulmonary source of infection, host comorbidities, virulence genes, and healthcare acquisition are far more important drivers of mortality.

Antimicrobial resistance is increasing in Escherichia coli, particularly among extended-spectrum β-lactamase (ESBL)–producing E. coli. However, the role that antimicrobial resistance plays in driving bacterial-associated mortality compared with other factors is unclear.

To address this issue, investigators examined E. coli bacteremia in 545 adults from seven tertiary care hospitals in the Paris metropolitan area. Strains were whole-genome sequenced to determine clonal complex type, presence of virulence and antimicrobial resistance genes, and phylogroup status. Patient characteristics were captured prospectively to determine risks for death up to 28 days after the index blood culture. Bacterial genotypic and clinical characteristics determin…

Reviewing Author

George Sakoulas, MD

Disclosures

Consultant/Advisory BoardParatek Pharmaceuticals; Nestle Corp.; AbbVie; Shionogi

Speaker’s BureauAllergan/AbbVie; Paratek Pharmaceuticals; Nestle Corp.

RoyaltiesUpToDate

Editorial BoardsAntimicrobial Agents and Chemotherapy; Open Forum Infectious Diseases