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Novel coronaviruses causing severe respiratory infection (Middle East respiratory syndrome [MERS], severe acute respiratory syndrome [SARS], and now COVID-19) are associated with psychiatric and neuropsychiatric complications, due to a combination of viral central nervous system effects, immune response, physiologic compromise from infection, medications, and psychosocial stress, the latter being uniquely worse with COVID-19 social-lockdown effects. Researchers conducted a systematic review and meta-analysis of 65 studies and 7 preprints from multiple countries, covering 3559 patients from adolescents to seniors.
The most common acute effects, from 25 studies of SARS and MERS, included insomnia (41% of patients), anxiety (36%), concentration…