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Due to widespread use of antibiotics, multidrug-resistant organisms have emerged as causes of spontaneous bacterial peritonitis (SBP). Typically, third-generation cephalosporins (TGCs) are recommended for empiric treatment of hospitalized patients with SBP while awaiting culture results. It is unclear if the empiric use of a broader-spectrum antibiotic, such as carbapenem, would improve outcomes in this setting.
To compare outcomes of carbapenem and TGCs in this setting, researchers conducted a retrospective study involving 865 consecutive hospitalized patients in Korea receiving empirical antibiotic treatment for a first episode of SBP. Severity of liver disease was assessed by several methods, including the model for end-stage liver diseas…