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Factor V Leiden is a genetic mutation associated with a prothrombotic state. Carrying the mutation is associated with four times the risk for venous thromboembolism. Some experts have posited that people with the mutation and established coronary heart disease (CHD) could be at an even higher excess risk. Investigators combined individual-level data from 25 studies to determine the association of factor V Leiden with the risk for atherothrombotic events (composite outcome of CHD death or myocardial infarction) among 69,681 people with established CHD. Most of the participants were men (73%); across the studies, the mean age ranged from 60 to 71 years, and median follow-up was 1.0 to 10.6 years.
Overall, 3190 people were heterogeneous for fac…