Noninvasively Predicting Liver-Related Outcomes in Patients with Advanced Liver Disease Who Cleared HCV Infection

After clearance of chronic hepatitis C virus (HCV) infection, patients with advanced liver fibrosis are still at risk for hepatic decompensation. Few data are available on noninvasive methods of predicting post–sustained virologic response (SVR) liver-related outcomes in this population.

In a retrospective study in HCV patients with advanced liver disease — defined as liver stiffness measurement (LSM) using transient elastography of ≥10kPa, hepatic venous pressure gradient (HVPG) ≥6 mmHg, or advanced fibrosis/cirrhosis on liver biopsy — researchers evaluated the prognostic value of pre- and posttreatment LSM and von Willebrand factor antigen to platelet ratio (VITRO) for liver-related outcomes. Patients achieved SVR to interferon-free anti-H…