Effect of Diffusion-Weighted Brain Lesions After Intracerebral Hemorrhage

In a patient-level meta-analysis of four studies, DWI lesions were associated with poor outcome in those with deep hemorrhages.

MRI studies have documented lesions on diffusion-weighted imaging (DWI) in a subset of patients with intracerebral hemorrhage (ICH). The pathophysiology of these lesions and their effect on neurologic outcome is unclear. These authors pooled the data from four studies of patients with ICH to investigate factors associated with DWI lesions and subsequent outcomes in patients with and without DWI lesions, according to hemorrhage location (deep or lobar). Poor outcome was defined as modified Rankin Scale score of 4 to 6.

From the four studies, 1752 patients (mean age, 61 years; 58% men) had MRI data suitable for analysis. MRI was performed at a median of 1.5 days after the ICH, and baseline hematoma volume in the four studies ranged from 9 to 4…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Effect of Diffusion-Weighted Brain Lesions After Intracerebral Hemorrhage

Topics

Reviewing Author