A case report provides evidence for transplacental mother-to-child transmission of SARS-CoV-2 resulting in symptomatic neonatal infection.
Neonatal SARS-CoV-2 infection has been reported in the setting of maternal COVID-19, but whether the virus was transmitted across the placenta, during the birth process, or after birth remains unclear. In this case study, investigators in France present the strongest evidence to date for transplacental SARS-CoV-2 transmission.
A pregnant 23-year-old woman presented at 35 weeks' gestation with 2 days of fever and respiratory symptoms. On admission, she had lymphopenia and elevated liver enzymes and inflammatory markers. SARS-CoV-2 was detected in blood as well as nasopharyngeal and vaginal swabs. Three days later, fetal heart rate tracing was concerning, prompting cesarean delivery of a 2.5-kg boy. SARS-CoV-2 was detected in amniotic fluid. B…
Reviewing Authors
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)