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Localizing brain processes underlying manic episodes might inform pathogenesis and identify therapeutic targets. Because of reports of mania after specific brain injuries, investigators searched for underlying brain connectivity patterns in 41 patients with brain lesions and subsequent mania (mean age, 55; median time between lesion and onset of mania, 3 years).
These lesions were anatomically diverse, but when they were superimposed onto a normative human brain atlas (based on 1000 healthy people), patterns of connectivity emerged. The resulting mania-lesion network map was characterized by connectivity to the right orbitofrontal cortex, right lateral temporal cortex, and right frontal polar cortex. These network findings were confirmed in …