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Transient global amnesia (TGA) is a benign but highly distressing event of antegrade amnesia that usually lasts a few hours. Some events are associated with triggers that cause transient intracranial venous hypertension (e.g., Valsalva maneuver, sexual activity, emotional shock). Results of diagnostic evaluation, including imaging, usually are normal, and often no sequelae occur. In a 25-year retrospective study, Mayo Clinic investigators explored the factors associated with recurrence.
Of 1044 patients, 86% were seen for first episodes of TGA, and 14% had recurrent episodes at the time of evaluation. Patients with a single episode were older than those with recurrent episodes (mean age, 65 vs. 58). Nearly all patients with recurrent TGA had…