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Infections in critically ill patients present a perfect storm of antimicrobial treatment failure, bringing together severe infection, the immunocompromising state of sepsis and possible organ failure, heterogeneity in drug clearance, and need for timely appropriate therapy. Traditional target dosing for β-lactams has focused on achieving free drug concentrations above minimum inhibitory concentration (fT>MIC) for >50% of the dosing interval. However, recent data indicate that achieving this goal for 100% of the dosing interval may be optimal. Researchers have now assessed the relevance of achieving β-lactam fT>MIC of 100% in 206 patients in an intensive care unit (ICU) at an academic hospital who received β-lactam therapy and had therapeuti…