Does Cytomegalovirus Infection Increase Mortality as We Age?

In a multicohort analysis of older adults, all-cause, cardiovascular, and noncardiovascular mortality was not significantly more common in those who were CMV seropositive compared with those who were seronegative.

Worldwide, between 70% and 100% of older adults are infected with cytomegalovirus (CMV). While the morbidity and mortality associated with CMV infections in immunocompromised patients are well established, the effect of latent infection among immunocompetent persons is unknown. Recently, linkages between CMV infection and cardiovascular disease, diabetes, and overall mortality have been reported. However, these associations were likely confounded by differences among groups. To examine the potential associations further, researchers from northern Europe assessed five observational cohorts with a total of 10,122 community-dwelling adults ranging from 59 to 93 years old. Each cohort had large numbers of covariates that enabled adjustments for…

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Does Cytomegalovirus Infection Increase Mortality as We Age?

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Reviewing Author