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Super refractory status epilepticus (SRSE) is one of the most challenging disorders to treat in the neurointensive care unit. Often, clinicians must resort to less-established treatments with regards to efficacy and safety. Ketamine is one such therapy. It is not only important to know how effective ketamine might be, but also whether it has any significant adverse effects on intracranial pressure or cardiovascular support.
The authors of this large retrospective cohort study sought to examine the efficacy of high-dose ketamine and its effects on systemic and brain physiological measures. Of 261 SRSE patients treated at a tertiary care center from 2009 to 2018, 68 (26%) had received ketamine. Seizures were completely controlled in 63% of ket…