Durability of Fecal Microbiota Transplantation for C. difficile Infection

In a retrospective study of patients who underwent FMT and had continued risks for Clostridioides difficile disease, antibiotic exposure was the only significant risk factor for recurrence.

Observational studies have indicated a 90% cure rate with fecal microbiota transplantation (FMT) for cases of recurrent Clostridioides difficile infection (CDI). FMT has been postulated to work by restoring a diverse microbiological fecal milieu. If such a change occurs after FMT, an important question is how long does it last. That is, what is its durability? To answer this question, researchers at a single medical center retrospectively reviewed the outcomes of 460 patients with at least three prior CDI episodes who received FMT from September 2012 to January 2018. Patients were divided into two groups and followed for up to 1 year after FMT. The risk factor exposed cohort consisted of patients with subsequent risks for CDI, including und…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Durability of Fecal Microbiota Transplantation for C. difficile Infection

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Reviewing Author