Identifying Febrile Children at Risk for MIS-C

Compared with febrile outpatients, children hospitalized for multisystem inflammatory disorder had higher fever, more symptoms, lower absolute lymphocyte counts, and higher CRP levels.

Identifying children at risk for multisystem inflammatory disorder (MIS-C) associated with SARS-CoV-2 infection has been a concern for pediatricians, given the many children with febrile illnesses. In a retrospective case-control study, researchers at a New York City medical center compared clinical features between 44 children with MIS-C who received inpatient treatment with intravenous immunoglobulin and corticosteroids and 181 febrile outpatients (mostly telehealth visits).

Median age was 8.2 years for MIS-C patients, compared with 5.0 years for 158 outpatients seen in the clinic (or by telehealth) and 2.2 years for 23 controls seen in the emergency department. Half of patients were Hispanic. COVID-19 exposure was reported in 57% of MIS-C…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Identifying Febrile Children at Risk for MIS-C

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Reviewing Author