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Individual randomized, controlled trials have demonstrated that surgical decompression for large hemispheric stroke can reduce the risk for death and increase the proportion of patients with favorable functional outcomes, but these studies have had limited power to explore whether this treatment effect is robust across various subgroups of patients. In the largest systematic review and meta-analysis of individual patient-level data from these randomized clinical trials, investigators sought to confirm the overall treatment effect and look for heterogeneity of this treatment effect across several prespecified subgroups.
Using data from seven trials with a total of 488 patients, investigators confirmed that surgical decompression was associate…