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Many treatments exist for fibromyalgia, but evidence to support them is limited. In this systematic review and meta-analysis of 224 randomized trials that involved 30,000 participants (95% women), researchers evaluated the effectiveness of dozens of treatments.
Active treatments were compared with placebo, sham, or no intervention (i.e., not with other active treatments). High-quality evidence (i.e., outcomes unlikely to change with additional trial evidence) showed that, in the short term (<3 months), cognitive-behavioral therapy significantly reduced pain, and antidepressants significantly improved quality of life (QOL); in the medium term (3–12 months), antidepressants and γ-hydroxybutyrate significantly reduced pain and improved QOL. How…